4ctn: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ctn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CTN FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ctn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CTN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=M8P:N-[(2Z,5R,7R,8S,9S,10R)-8,9,10-TRIHYDROXY-7-(HYDROXYMETHYL)-4-OXO-6-OXA-1-THIA-3-AZASPIRO[4.5]DEC-2-YLIDENE]NAPHTHALENE-2-CARBOXAMIDE'>M8P</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=M8P:N-[(2Z,5R,7R,8S,9S,10R)-8,9,10-TRIHYDROXY-7-(HYDROXYMETHYL)-4-OXO-6-OXA-1-THIA-3-AZASPIRO[4.5]DEC-2-YLIDENE]NAPHTHALENE-2-CARBOXAMIDE'>M8P</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ctn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ctn OCA], [https://pdbe.org/4ctn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ctn RCSB], [https://www.ebi.ac.uk/pdbsum/4ctn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ctn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ctn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ctn OCA], [https://pdbe.org/4ctn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ctn RCSB], [https://www.ebi.ac.uk/pdbsum/4ctn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ctn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Latest revision as of 12:16, 20 December 2023
Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods
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