2k9b: Difference between revisions

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==Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy==
==Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy==
<StructureSection load='2k9b' size='340' side='right'caption='[[2k9b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2k9b' size='340' side='right'caption='[[2k9b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k9b]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9B FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phyllomedusa_distincta Phyllomedusa distincta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9B FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9b OCA], [https://pdbe.org/2k9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9b RCSB], [https://www.ebi.ac.uk/pdbsum/2k9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9b OCA], [https://pdbe.org/2k9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9b RCSB], [https://www.ebi.ac.uk/pdbsum/2k9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DDSK_PHYDS DDSK_PHYDS]] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>
[https://www.uniprot.org/uniprot/DRS1_PHYDS DRS1_PHYDS] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antiprotozoal activity against T.cruzi. Has antifungal activity against the yeasts C.tropicalis (MIC=10.1 uM), C.guilliermondii (MIC=20.3 uM), C.albicans (MIC=20.3 uM) and C.albicans ATCC 1023 (MIC=10.1 uM). Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.<ref>PMID:10477123</ref> <ref>PMID:12379643</ref> <ref>PMID:17409003</ref> <ref>PMID:17442605</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aisenbrey, C]]
[[Category: Phyllomedusa distincta]]
[[Category: Almeida, F C.L]]
[[Category: Aisenbrey C]]
[[Category: Bechinger, B]]
[[Category: Almeida FCL]]
[[Category: Bemquerer, M P]]
[[Category: Bechinger B]]
[[Category: Moraes, C M]]
[[Category: Bemquerer MP]]
[[Category: Pilo-Veloso, D]]
[[Category: Moraes CM]]
[[Category: Resende, J M]]
[[Category: Pilo-Veloso D]]
[[Category: Valente, A]]
[[Category: Resende JM]]
[[Category: Verly, R M]]
[[Category: Valente A]]
[[Category: Amphibian defense peptide]]
[[Category: Verly RM]]
[[Category: Amphipathic alpha-helix]]
[[Category: Antibiotic]]
[[Category: Antimicrobial]]
[[Category: Antimicrobial protein]]
[[Category: C-terminal carboxyamidation]]
[[Category: Membrane protein structure determination]]
[[Category: Secreted]]
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