8i7q: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "8i7q" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cobalt and Calcium coordinated Concanavalin A at pH 7.4 from Canavalia ensiformis== | |||
<StructureSection load='8i7q' size='340' side='right'caption='[[8i7q]], [[Resolution|resolution]] 2.83Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8i7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I7Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i7q OCA], [https://pdbe.org/8i7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i7q RCSB], [https://www.ebi.ac.uk/pdbsum/8i7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i7q ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Concanavalin A (ConA) has an intrinsic binding affinity to carbohydrates. Here, we obtained Co(2+)-Ca(2+)-ConA (2.83 A, PDB: 8I7Q) via X-ray crystallography by substituting native ConA (Mn(2+)-Ca(2+)); it has binding selectivity for high-mannose N-glycan similar to native ConA. Our findings may thus inform antiviral reagent design. | |||
Selective interactions of Co(2+)-Ca(2+)-concanavalin A with high mannose N-glycans.,Hwang Y, Jeong JH, Lee DH, Lee SJ Dalton Trans. 2023 Dec 12. doi: 10.1039/d3dt03575a. PMID:38086668<ref>PMID:38086668</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Hwang | <div class="pdbe-citations 8i7q" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Canavalia ensiformis]] | |||
[[Category: Large Structures]] | |||
[[Category: Hwang Y]] | |||
[[Category: Jeong JH]] | |||
[[Category: Lee SJ]] | |||
