1gh7: Difference between revisions

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<StructureSection load='1gh7' size='340' side='right'caption='[[1gh7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1gh7' size='340' side='right'caption='[[1gh7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GH7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GH7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gh7 OCA], [https://pdbe.org/1gh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gh7 RCSB], [https://www.ebi.ac.uk/pdbsum/1gh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gh7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gh7 OCA], [https://pdbe.org/1gh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gh7 RCSB], [https://www.ebi.ac.uk/pdbsum/1gh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gh7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[https://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>
[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[https://omim.org/entry/614370 614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.  
[https://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carr, P D]]
[[Category: Carr PD]]
[[Category: Church, A P]]
[[Category: Church AP]]
[[Category: Ford, S C]]
[[Category: Ford SC]]
[[Category: Gustin, S E]]
[[Category: Gustin SE]]
[[Category: Mann, D A]]
[[Category: Mann DA]]
[[Category: Murphy, J M]]
[[Category: Murphy JM]]
[[Category: Ollis, D L]]
[[Category: Ollis DL]]
[[Category: Walker, I]]
[[Category: Walker I]]
[[Category: Woltring, D M]]
[[Category: Woltring DM]]
[[Category: Young, I G]]
[[Category: Young IG]]
[[Category: Cytokine receptor]]
[[Category: Dimer of interlocking chains of fibronectin-iii domains four fibronectin-iii domains per chain]]
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