1gjb: Difference between revisions

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<StructureSection load='1gjb' size='340' side='right'caption='[[1gjb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1gjb' size='340' side='right'caption='[[1gjb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gjb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJB FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gjb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=130:2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>130</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c5x|1c5x]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=130:2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>130</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjb OCA], [https://pdbe.org/1gjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjb RCSB], [https://www.ebi.ac.uk/pdbsum/1gjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjb OCA], [https://pdbe.org/1gjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjb RCSB], [https://www.ebi.ac.uk/pdbsum/1gjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjb ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.  
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: U-plasminogen activator]]
[[Category: Allen D]]
[[Category: Allen, D]]
[[Category: Breitenbucher JG]]
[[Category: Breitenbucher, J G]]
[[Category: Hui H]]
[[Category: Hui, H]]
[[Category: Katz BA]]
[[Category: Katz, B A]]
[[Category: Luong C]]
[[Category: Luong, C]]
[[Category: Mackman RL]]
[[Category: Mackman, R L]]
[[Category: Martelli A]]
[[Category: Martelli, A]]
[[Category: McGee D]]
[[Category: McGee, D]]
[[Category: Spencer JR]]
[[Category: Spencer, J R]]
[[Category: Sprengeler PA]]
[[Category: Sprengeler, P A]]
[[Category: Verner E]]
[[Category: Verner, E]]
[[Category: Blood clotting]]
[[Category: H2o displacement]]
[[Category: Hydrolase]]
[[Category: Selectivity at s1]]
[[Category: Ser190/ala190 protease]]
[[Category: Structure-based drug design]]
[[Category: Tpa]]
[[Category: Upa]]
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