1uef: Difference between revisions

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<StructureSection load='1uef' size='340' side='right'caption='[[1uef]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1uef' size='340' side='right'caption='[[1uef]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1uef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEF FirstGlance]. <br>
<table><tr><td colspan='2'>[[1uef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEF FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transferase Transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uef OCA], [https://pdbe.org/1uef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uef RCSB], [https://www.ebi.ac.uk/pdbsum/1uef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uef ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uef OCA], [https://pdbe.org/1uef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uef RCSB], [https://www.ebi.ac.uk/pdbsum/1uef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uef ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DOK1_MOUSE DOK1_MOUSE]] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). [[https://www.uniprot.org/uniprot/RET_MOUSE RET_MOUSE]] Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.<ref>PMID:17322904</ref> <ref>PMID:20237269</ref> 
[https://www.uniprot.org/uniprot/DOK1_MOUSE DOK1_MOUSE] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Transferase]]
[[Category: Ding Y]]
[[Category: Ding, Y]]
[[Category: Liu Y]]
[[Category: Liu, Y]]
[[Category: Lou Z]]
[[Category: Lou, Z]]
[[Category: Qiang B]]
[[Category: Qiang, B]]
[[Category: Rao Z]]
[[Category: Rao, Z]]
[[Category: Shi N]]
[[Category: Shi, N]]
[[Category: Yan J]]
[[Category: Yan, J]]
[[Category: Ye S]]
[[Category: Ye, S]]
[[Category: Zhou W]]
[[Category: Zhou, W]]
[[Category: Phosphotyrosine binding domain]]
[[Category: Protein binding]]
[[Category: Protein binding-transferase complex]]
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