1v91: Difference between revisions

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==Solution structure of insectidal toxin delta-paluIT2-NH2==
==Solution structure of insectidal toxin delta-paluIT2-NH2==
<StructureSection load='1v91' size='340' side='right'caption='[[1v91]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1v91' size='340' side='right'caption='[[1v91]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1v91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paracoelotes_luctuosus Paracoelotes luctuosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V91 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1v91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pireneitega_luctuosa Pireneitega luctuosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V91 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1v90|1v90]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v91 OCA], [https://pdbe.org/1v91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v91 RCSB], [https://www.ebi.ac.uk/pdbsum/1v91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v91 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v91 OCA], [https://pdbe.org/1v91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v91 RCSB], [https://www.ebi.ac.uk/pdbsum/1v91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v91 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TXDP2_PIRLC TXDP2_PIRLC]] Insecticidal toxin. Lethal to lepidopteran larvae. No adverse affects when intracerebroventricularly injected in mice at a dose of 0.2 ug but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 ug. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation.<ref>PMID:10971590</ref> <ref>PMID:15683238</ref>
[https://www.uniprot.org/uniprot/T3D1B_PIRLC T3D1B_PIRLC] Insecticidal toxin. Lethal to lepidopteran larvae. No adverse affects when intracerebroventricularly injected in mice at a dose of 0.2 ug but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 ug. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation.<ref>PMID:10971590</ref> <ref>PMID:15683238</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Paracoelotes luctuosus]]
[[Category: Pireneitega luctuosa]]
[[Category: Bosmans, F]]
[[Category: Bosmans F]]
[[Category: Chagot, B]]
[[Category: Chagot B]]
[[Category: Corzo, G]]
[[Category: Corzo G]]
[[Category: Darbon, H]]
[[Category: Darbon H]]
[[Category: Ferrat, G]]
[[Category: Ferrat G]]
[[Category: Nakajima, T]]
[[Category: Nakajima T]]
[[Category: Pimentel, C]]
[[Category: Pimentel C]]
[[Category: Tytgat, J]]
[[Category: Tytgat J]]
[[Category: Amidation]]
[[Category: Ionic channel inhibitor]]
[[Category: Neurotoxin]]
[[Category: Sodium channel inhibitor]]
[[Category: Toxin]]
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