2o6l: Difference between revisions

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<StructureSection load='2o6l' size='340' side='right'caption='[[2o6l]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2o6l' size='340' side='right'caption='[[2o6l]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2o6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O6L FirstGlance]. <br>
<table><tr><td colspan='2'>[[2o6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O6L FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGT2B7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glucuronosyltransferase Glucuronosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.17 2.4.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6l OCA], [https://pdbe.org/2o6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o6l RCSB], [https://www.ebi.ac.uk/pdbsum/2o6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o6l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6l OCA], [https://pdbe.org/2o6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o6l RCSB], [https://www.ebi.ac.uk/pdbsum/2o6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o6l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/UD2B7_HUMAN UD2B7_HUMAN]] UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.<ref>PMID:17442341</ref>  Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).<ref>PMID:17442341</ref>
[https://www.uniprot.org/uniprot/UD2B7_HUMAN UD2B7_HUMAN] UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.<ref>PMID:17442341</ref>  Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).<ref>PMID:17442341</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glucuronosyltransferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Miley, M J]]
[[Category: Miley MJ]]
[[Category: Redinbo, M R]]
[[Category: Redinbo MR]]
[[Category: Drug metabolism]]
[[Category: Enzyme]]
[[Category: Mad]]
[[Category: Nucleotide binding]]
[[Category: Rossman]]
[[Category: Sugar]]
[[Category: Transferase]]
[[Category: Udp-glucuronosyltransferase]]
[[Category: Ugt]]
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