2oie: Difference between revisions
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<StructureSection load='2oie' size='340' side='right'caption='[[2oie]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2oie' size='340' side='right'caption='[[2oie]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2oie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2oie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oie OCA], [https://pdbe.org/2oie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oie RCSB], [https://www.ebi.ac.uk/pdbsum/2oie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oie ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oie OCA], [https://pdbe.org/2oie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oie RCSB], [https://www.ebi.ac.uk/pdbsum/2oie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oie ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DCTP1_MOUSE DCTP1_MOUSE] Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.<ref>PMID:17320107</ref> <ref>PMID:19220460</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Bartlam | [[Category: Bartlam M]] | ||
[[Category: Chen | [[Category: Chen W]] | ||
[[Category: Liao | [[Category: Liao S]] | ||
[[Category: Liu | [[Category: Liu Y]] | ||
[[Category: Rao | [[Category: Rao Z]] | ||
[[Category: Wu | [[Category: Wu B]] | ||
[[Category: Zhang | [[Category: Zhang J]] | ||
[[Category: Zhao | [[Category: Zhao Q]] | ||
