2okg: Difference between revisions

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<StructureSection load='2okg' size='340' side='right'caption='[[2okg]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='2okg' size='340' side='right'caption='[[2okg]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2okg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKG FirstGlance]. <br>
<table><tr><td colspan='2'>[[2okg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cggR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okg OCA], [https://pdbe.org/2okg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okg RCSB], [https://www.ebi.ac.uk/pdbsum/2okg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okg ProSAT], [https://www.topsan.org/Proteins/MCSG/2okg TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okg OCA], [https://pdbe.org/2okg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okg RCSB], [https://www.ebi.ac.uk/pdbsum/2okg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okg ProSAT], [https://www.topsan.org/Proteins/MCSG/2okg TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CGGR_BACSU CGGR_BACSU]] In the absence of glucose, represses the transcription of the gapA operon, which encodes five key glycolytic enzymes. Binds specifically to the cggR-gapA promoter region and blocks the progression of the RNA polymerase, leading to the arrest of the transcription.<ref>PMID:10799476</ref> <ref>PMID:12622823</ref> <ref>PMID:20462860</ref>
[https://www.uniprot.org/uniprot/CGGR_BACSU CGGR_BACSU] In the absence of glucose, represses the transcription of the gapA operon, which encodes five key glycolytic enzymes. Binds specifically to the cggR-gapA promoter region and blocks the progression of the RNA polymerase, leading to the arrest of the transcription.<ref>PMID:10799476</ref> <ref>PMID:12622823</ref> <ref>PMID:20462860</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Structural genomic]]
[[Category: Moy SF]]
[[Category: Moy, S F]]
[[Category: Otwinowski Z]]
[[Category: Otwinowski, Z]]
[[Category: Rezacova P]]
[[Category: Rezacova, P]]
[[Category: Alpha/beta/alpha sandwich]]
[[Category: Mcsg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Rossmann-like fold]]
[[Category: Transcription]]
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