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==HIGH-RESOLUTION STRUCTURE OF AN HIV ZINC FINGERLIKE DOMAIN VIA A NEW NMR-BASED DISTANCE GEOMETRY APPROACH==
==HIGH-RESOLUTION STRUCTURE OF AN HIV ZINC FINGERLIKE DOMAIN VIA A NEW NMR-BASED DISTANCE GEOMETRY APPROACH==
<StructureSection load='2znf' size='340' side='right'caption='[[2znf]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
<StructureSection load='2znf' size='340' side='right'caption='[[2znf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2znf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2znf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znf OCA], [https://pdbe.org/2znf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znf RCSB], [https://www.ebi.ac.uk/pdbsum/2znf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znf OCA], [https://pdbe.org/2znf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znf RCSB], [https://www.ebi.ac.uk/pdbsum/2znf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GAG_HV1LW GAG_HV1LW]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu.  Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.  p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
[https://www.uniprot.org/uniprot/Q9J188_9HIV1 Q9J188_9HIV1]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hare, D R]]
[[Category: Hare DR]]
[[Category: Kim, B]]
[[Category: Kim B]]
[[Category: South, T L]]
[[Category: South TL]]
[[Category: Summers, M F]]
[[Category: Summers MF]]
[[Category: Aids-related virus gag polyprotein]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/2znf"