8fw2: Difference between revisions
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The entry | ==Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry== | ||
<StructureSection load='8fw2' size='340' side='right'caption='[[8fw2]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8fw2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FW2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fw2 OCA], [https://pdbe.org/8fw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8fw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fw2 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Berger S]] | |||
[[Category: Faustin B]] | |||
[[Category: Kumar N]] | |||
[[Category: Matico RE]] | |||
[[Category: Medley Q]] | |||
[[Category: Miller R]] | |||
[[Category: Ricketts MD]] | |||
[[Category: Sharma S]] | |||
[[Category: Somani S]] | |||
[[Category: Steele RA]] | |||
[[Category: Yu X]] | |||
Latest revision as of 11:01, 3 January 2024
Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry
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