8gcm: Difference between revisions
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==Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein== | |||
<StructureSection load='8gcm' size='340' side='right'caption='[[8gcm]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8gcm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YX9:(5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one'>YX9</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcm OCA], [https://pdbe.org/8gcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcm RCSB], [https://www.ebi.ac.uk/pdbsum/8gcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Huang SM]] | |||
[[Category: Liu L]] | |||
[[Category: Mu J]] | |||
[[Category: Sheng C]] | |||
[[Category: Sun J]] | |||
[[Category: Xiong MY]] | |||
Revision as of 11:01, 3 January 2024
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
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