Ribavirin1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 19: | Line 19: | ||
Nucleoside transporters facilitate the transport of nucleosides across cell membranes to be used in protein synthesis. Concentrated NTs (CNTs) use the energy of ion gradients for active transportation , while equilibrative NTs (ENTs) transport nucleosides passively down their concentration gradient. Ribavirin is a substrate of ENT1, ENT2, and CNT2. CNT2 binds to the ribose of the ribavirin via hydrogen bonding involving glutamic acid at position 332, asparagine at position 368, and serine at position 371<ref>doi:10.7554/eLife.03604</ref>. | Nucleoside transporters facilitate the transport of nucleosides across cell membranes to be used in protein synthesis. Concentrated NTs (CNTs) use the energy of ion gradients for active transportation , while equilibrative NTs (ENTs) transport nucleosides passively down their concentration gradient. Ribavirin is a substrate of ENT1, ENT2, and CNT2. CNT2 binds to the ribose of the ribavirin via hydrogen bonding involving glutamic acid at position 332, asparagine at position 368, and serine at position 371<ref>doi:10.7554/eLife.03604</ref>. | ||
<scene name='55/559112/Ribavirin_interacting_4pb1/1'> | <scene name='55/559112/Ribavirin_interacting_4pb1/1'>Ribavirin with 4PB1</scene> ([[4pb1]]) | ||
== Disease == | == Disease == | ||
===Hepatitis C=== | ===Hepatitis C=== | ||
