8c53: Difference between revisions
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==Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing== | |||
<StructureSection load='8c53' size='340' side='right'caption='[[8c53]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8c53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C53 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c53 OCA], [https://pdbe.org/8c53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c53 RCSB], [https://www.ebi.ac.uk/pdbsum/8c53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c53 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/IMDH_TRYBB IMDH_TRYBB] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Nachtschatt | [[Category: Large Structures]] | ||
[[Category: | [[Category: Trypanosoma brucei]] | ||
[[Category: | [[Category: Boger J]] | ||
[[Category: | [[Category: Bourenkov G]] | ||
[[Category: | [[Category: Duden R]] | ||
[[Category: Harms M]] | |||
[[Category: Kaiser J]] | |||
[[Category: Lahey-Rudolph JM]] | |||
[[Category: Nachtschatt S]] | |||
[[Category: Redecke L]] | |||
[[Category: Schneider T]] | |||
[[Category: Schoenherr R]] | |||
[[Category: Wobbe M]] | |||
Latest revision as of 10:03, 17 January 2024
Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing
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