8ss0: Difference between revisions

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'''Unreleased structure'''


The entry 8ss0 is ON HOLD  until Paper Publication
==Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol==
 
<StructureSection load='8ss0' size='340' side='right'caption='[[8ss0]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
Authors: Hargrove, T.Y., Wawrzak, Z., Guengerich, F.P., Lepesheva, G.I.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ss0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SS0 FirstGlance]. <br>
Description: Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WQR:3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al'>WQR</scene></td></tr>
[[Category: Wawrzak, Z]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ss0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ss0 OCA], [https://pdbe.org/8ss0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ss0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ss0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ss0 ProSAT]</span></td></tr>
[[Category: Hargrove, T.Y]]
</table>
[[Category: Lepesheva, G.I]]
== Function ==
[[Category: Guengerich, F.P]]
[https://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Guengerich FP]]
[[Category: Hargrove TY]]
[[Category: Lepesheva GI]]
[[Category: Wawrzak Z]]
Retrieved from "https://proteopedia.org/8ss0"