8c7d: Difference between revisions
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==Structure of the GEF Kalirin DH2 Domain== | |||
<StructureSection load='8c7d' size='340' side='right'caption='[[8c7d]], [[Resolution|resolution]] 1.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8c7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C7D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c7d OCA], [https://pdbe.org/8c7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c7d RCSB], [https://www.ebi.ac.uk/pdbsum/8c7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c7d ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: Thompson | [https://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.<ref>PMID:10023074</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bountra C]] | |||
[[Category: Brennan PE]] | |||
[[Category: Callens MC]] | |||
[[Category: Gray JL]] | |||
[[Category: Thompson AP]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:24, 24 January 2024
Structure of the GEF Kalirin DH2 Domain
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