6hll: Difference between revisions

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<StructureSection load='6hll' size='340' side='right'caption='[[6hll]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
<StructureSection load='6hll' size='340' side='right'caption='[[6hll]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HLL FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HLL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GBK:(2~{S},3~{S})-~{N}-[(2-methoxyphenyl)methyl]-2-phenyl-piperidin-3-amine'>GBK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.27&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TACR1, NK1R, TAC1R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBK:(2~{S},3~{S})-~{N}-[(2-methoxyphenyl)methyl]-2-phenyl-piperidin-3-amine'>GBK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hll OCA], [http://pdbe.org/6hll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hll RCSB], [http://www.ebi.ac.uk/pdbsum/6hll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hll ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hll OCA], [https://pdbe.org/6hll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hll RCSB], [https://www.ebi.ac.uk/pdbsum/6hll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hll ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN]] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.  
[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dore, A S]]
[[Category: Pyrococcus abyssi GE5]]
[[Category: Ehrenmann, J]]
[[Category: Dore AS]]
[[Category: Klenk, C]]
[[Category: Ehrenmann J]]
[[Category: Pluckthun, A]]
[[Category: Klenk C]]
[[Category: Rucktooa, P]]
[[Category: Pluckthun A]]
[[Category: Schoppe, J]]
[[Category: Rucktooa P]]
[[Category: Schutz, M]]
[[Category: Schoppe J]]
[[Category: 7-tm]]
[[Category: Schutz M]]
[[Category: Gpcr]]
[[Category: Membrane protein]]
[[Category: Signalling protein]]
Retrieved from "https://proteopedia.org/6hll"