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==Crystal structure of DmTailor in complex with CACAGU RNA==
==Crystal structure of DmTailor in complex with CACAGU RNA==
<StructureSection load='6i0v' size='340' side='right' caption='[[6i0v]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='6i0v' size='340' side='right'caption='[[6i0v]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6i0v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0V FirstGlance]. <br>
<table><tr><td colspan='2'>[[6i0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I0V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.851&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6i0s|6i0s]], [[6i0t|6i0t]], [[6i0u|6i0u]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_uridylyltransferase RNA uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.52 2.7.7.52] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0v OCA], [https://pdbe.org/6i0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i0v RCSB], [https://www.ebi.ac.uk/pdbsum/6i0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0v OCA], [http://pdbe.org/6i0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0v RCSB], [http://www.ebi.ac.uk/pdbsum/6i0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TUTT_DROME TUTT_DROME]] Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis.<ref>PMID:26145174</ref> <ref>PMID:26145176</ref>
[https://www.uniprot.org/uniprot/TUTT_DROME TUTT_DROME] Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis.<ref>PMID:26145174</ref> <ref>PMID:26145176</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6i0v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6i0v" style="background-color:#fffaf0;"></div>
==See Also==
*[[RNA uridylyltransferase|RNA uridylyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: RNA uridylyltransferase]]
[[Category: Drosophila melanogaster]]
[[Category: Ivascu, A]]
[[Category: Large Structures]]
[[Category: Jinek, M]]
[[Category: Ivascu A]]
[[Category: Kroupova, A]]
[[Category: Jinek M]]
[[Category: Nucleotidyl transferase]]
[[Category: Kroupova A]]
[[Category: Terminal uridyl transferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/6i0v"