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'''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA''' | '''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA]. | |||
==Reference== | ==Reference== | ||
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525381 8525381] | A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525381 8525381] | ||
[[Category: Betts, L.]] | [[Category: Betts, L.]] | ||
[[Category: Veal, J M.]] | [[Category: Veal, J M.]] | ||
[[Category: | [[Category: Hairpin pna:dna triplex]] | ||
[[Category: | [[Category: Triplex watson-crick hoogsteen]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:17:08 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 02:17, 3 May 2008
PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA
Overview
The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.
About this Structure
Full crystallographic information is available from OCA.
Reference
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381 Page seeded by OCA on Sat May 3 05:17:08 2008
