6qlz: Difference between revisions

<table><tr><td colspan='2'>[[6qlz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QLZ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.343&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qlz OCA], [https://pdbe.org/6qlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qlz RCSB], [https://www.ebi.ac.uk/pdbsum/6qlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qlz ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>  

[[Category: Homo sapiens]]

[[Category: Boyd H]]

[[Category: Gunnarsson J]]

[[Category: Guo H]]

[[Category: Johansson P]]

[[Category: Martinelli L]]

[[Category: Wan PT]]