6s9j: Difference between revisions
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The | ==Crystal structure of TfR1 mimicry in complex with GP1 from MACV== | ||
<StructureSection load='6s9j' size='340' side='right'caption='[[6s9j]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s9j]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Machupo_mammarenavirus Machupo mammarenavirus] and [https://en.wikipedia.org/wiki/Neotoma_albigula Neotoma albigula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S9J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.698Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s9j OCA], [https://pdbe.org/6s9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s9j RCSB], [https://www.ebi.ac.uk/pdbsum/6s9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s9j ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8AZ57_MACHU Q8AZ57_MACHU] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Certain arenaviruses that circulate in rodent populations can cause life-threatening hemorrhagic fevers when they infect humans. Due to their efficient transmission, arenaviruses pose a severe risk for outbreaks and might be exploited as biological weapons. Effective countermeasures against these viruses are highly desired. Ideally, a single remedy would be effective against many or even all the pathogenic viruses in this family. However, despite the fact that all pathogenic arenaviruses from South America utilize transferrin receptor 1 (TfR1) as a cellular receptor, their viral glycoproteins are highly diversified, impeding efforts to isolate cross-neutralizing antibodies. Here we address this problem using a rational design approach to target TfR1-tropic arenaviruses with high potency and breadth. The pan-reactive molecule is highly effective against all arenaviruses that were tested, offering a universal therapeutic approach. Our design scheme avoids the shortcomings of previous immunoadhesins and can be used to combat other zoonotic pathogens. | |||
Rational design of universal immunotherapy for TfR1-tropic arenaviruses.,Cohen-Dvashi H, Amon R, Agans KN, Cross RW, Borenstein-Katz A, Mateo M, Baize S, Padler-Karavani V, Geisbert TW, Diskin R Nat Commun. 2020 Jan 3;11(1):67. doi: 10.1038/s41467-019-13924-6. PMID:31900422<ref>PMID:31900422</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6s9j" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]] | |||
*[[Transferrin receptor|Transferrin receptor]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Machupo mammarenavirus]] | |||
[[Category: Neotoma albigula]] | |||
[[Category: Cohen-Dvashi H]] | |||
[[Category: Diskin R]] | |||
