6scz: Difference between revisions

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<StructureSection load='6scz' size='340' side='right'caption='[[6scz]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
<StructureSection load='6scz' size='340' side='right'caption='[[6scz]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6scz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SCZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6scz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SCZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L7N:(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylidene-[(4~{R})-3-oxidanylidene-1,2-oxazolidin-4-yl]azanium'>L7N</scene>, <scene name='pdbligand=OJQ:[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl-(3-oxidanyl-1,2-oxazol-4-yl)azanium'>OJQ</scene>, <scene name='pdbligand=P4K:polyethylene+glycol'>P4K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alr, Rv3423c, MTCY78.06 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L7N:(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylidene-[(4~{R})-3-oxidanylidene-1,2-oxazolidin-4-yl]azanium'>L7N</scene>, <scene name='pdbligand=OJQ:[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl-(3-oxidanyl-1,2-oxazol-4-yl)azanium'>OJQ</scene>, <scene name='pdbligand=P4K:polyethylene+glycol'>P4K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alanine_racemase Alanine racemase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.1 5.1.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6scz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6scz OCA], [https://pdbe.org/6scz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6scz RCSB], [https://www.ebi.ac.uk/pdbsum/6scz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6scz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6scz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6scz OCA], [https://pdbe.org/6scz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6scz RCSB], [https://www.ebi.ac.uk/pdbsum/6scz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6scz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ALR_MYCTU ALR_MYCTU]] Catalyzes the interconversion of L-alanine and D-alanine.<ref>PMID:11267762</ref>
[https://www.uniprot.org/uniprot/ALR_MYCTU ALR_MYCTU] Catalyzes the interconversion of L-alanine and D-alanine.<ref>PMID:11267762</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alanine racemase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Carvalho, L P.S de]]
[[Category: Homsak M]]
[[Category: Chiara, C de]]
[[Category: Prosser G]]
[[Category: Homsak, M]]
[[Category: Purkiss A]]
[[Category: Prosser, G]]
[[Category: De Carvalho LPS]]
[[Category: Purkiss, A]]
[[Category: De Chiara C]]
[[Category: Enzyme]]
[[Category: Isomerase]]
[[Category: Peptidoglycan biosynthesis]]

Latest revision as of 12:39, 24 January 2024

Mycobacterium tuberculosis alanine racemase inhibited by DCS

6scz, resolution 1.57Å

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