6tgh: Difference between revisions
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==SHMT from | ==SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external aldimine and as non-covalent complex== | ||
<StructureSection load='6tgh' size='340' side='right'caption='[[6tgh]]' scene=''> | <StructureSection load='6tgh' size='340' side='right'caption='[[6tgh]], [[Resolution|resolution]] 2.12Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TGH FirstGlance]. <br> | <table><tr><td colspan='2'>[[6tgh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TGH FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgh OCA], [https://pdbe.org/6tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tgh RCSB], [https://www.ebi.ac.uk/pdbsum/6tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgh ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=EVM:L-Serine,+N-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylene]'>EVM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgh OCA], [https://pdbe.org/6tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tgh RCSB], [https://www.ebi.ac.uk/pdbsum/6tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgh ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | |||
==See Also== | ==See Also== | ||
*[[Serine hydroxymethyltransferase|Serine hydroxymethyltransferase]] | *[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Streptococcus thermophilus]] | ||
[[Category: Bujons J]] | |||
[[Category: Clapes P]] | |||
[[Category: Hernandez K]] | |||
[[Category: Petrillo G]] | |||
[[Category: Uson I]] | |||
Latest revision as of 13:01, 24 January 2024
SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external aldimine and as non-covalent complex
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