6tmd: Difference between revisions
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==Crystal structure of KANK2 ankyrin repeats mutant (A670V)== | ==Crystal structure of KANK2 ankyrin repeats mutant (A670V)== | ||
<StructureSection load='6tmd' size='340' side='right'caption='[[6tmd]]' scene=''> | <StructureSection load='6tmd' size='340' side='right'caption='[[6tmd]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMD OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6tmd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TMD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tmd OCA], [https://pdbe.org/6tmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tmd RCSB], [https://www.ebi.ac.uk/pdbsum/6tmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tmd ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref> | |||
==See Also== | |||
*[[Ankyrin repeat domain-containing protein 3D structures|Ankyrin repeat domain-containing protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Goult BT]] | [[Category: Goult BT]] | ||
[[Category: Khan R]] | [[Category: Khan R]] | ||
[[Category: Singh AK]] | [[Category: Singh AK]] | ||
Latest revision as of 13:05, 24 January 2024
Crystal structure of KANK2 ankyrin repeats mutant (A670V)
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