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==Fragment KCL_I013 in complex with IL-1-beta==
==Fragment KCL_I013 in complex with IL-1-beta==
<StructureSection load='6y8i' size='340' side='right'caption='[[6y8i]]' scene=''>
<StructureSection load='6y8i' size='340' side='right'caption='[[6y8i]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y8I FirstGlance]. <br>
<table><tr><td colspan='2'>[[6y8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y8I FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8i OCA], [http://pdbe.org/6y8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y8i RCSB], [http://www.ebi.ac.uk/pdbsum/6y8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8i ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OGE:1-(5-bromanylpyridin-2-yl)-3-(2-hydroxyethyl)urea'>OGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8i OCA], [https://pdbe.org/6y8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y8i RCSB], [https://www.ebi.ac.uk/pdbsum/6y8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: De Nicola GF]]
[[Category: De Nicola GF]]
[[Category: Nichols CE]]
[[Category: Nichols CE]]
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