6y8n: Difference between revisions

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<StructureSection load='6y8n' size='340' side='right'caption='[[6y8n]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='6y8n' size='340' side='right'caption='[[6y8n]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6y8n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19527 Atcc 19527]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y8N FirstGlance]. <br>
<table><tr><td colspan='2'>[[6y8n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_thermoresistibile Mycolicibacterium thermoresistibile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y8N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OGH:4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine'>OGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6y8l|6y8l]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OGH:4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine'>OGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB, RMCT_1109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1797 ATCC 19527])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8n OCA], [https://pdbe.org/6y8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y8n RCSB], [https://www.ebi.ac.uk/pdbsum/6y8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8n ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.6.2.2 5.6.2.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y8n OCA], [http://pdbe.org/6y8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y8n RCSB], [http://www.ebi.ac.uk/pdbsum/6y8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y8n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A117ILT2_MYCTH A0A117ILT2_MYCTH]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]  
[https://www.uniprot.org/uniprot/G7CIP8_MYCT3 G7CIP8_MYCT3] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6y8n" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6y8n" style="background-color:#fffaf0;"></div>
==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 19527]]
[[Category: DNA topoisomerase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Charrier, C]]
[[Category: Mycolicibacterium thermoresistibile]]
[[Category: Cooper, I R]]
[[Category: Charrier C]]
[[Category: Henderson, S R]]
[[Category: Cooper IR]]
[[Category: Lawson, D M]]
[[Category: Henderson SR]]
[[Category: Malone, B]]
[[Category: Lawson DM]]
[[Category: Maxwell, A]]
[[Category: Malone B]]
[[Category: McGarry, D H]]
[[Category: Maxwell A]]
[[Category: Mitchenall, L A]]
[[Category: McGarry DH]]
[[Category: Pichowicz, M]]
[[Category: Mitchenall LA]]
[[Category: Salisbury, A]]
[[Category: Pichowicz M]]
[[Category: Stevenson, C E.M]]
[[Category: Salisbury A]]
[[Category: Zholnerovych, Y]]
[[Category: Stevenson CEM]]
[[Category: Binding site]]
[[Category: Zholnerovych Y]]
[[Category: Dna binding protein]]
[[Category: Dna gyrase]]
[[Category: Inhibitor]]
[[Category: Isomerase]]
[[Category: Redx03863 iv]]
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