3iya: Difference between revisions

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iya OCA], [https://pdbe.org/3iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iya RCSB], [https://www.ebi.ac.uk/pdbsum/3iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iya ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity).  Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).  Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).

[[Category: Chen, J]]

[[Category: Chipman, P R]]

[[Category: Holdaway, H A]]

[[Category: Kuhn, R J]]

[[Category: Rossmann, M G]]

[[Category: Yu, I]]

[[Category: Virus]]