3j80: Difference between revisions

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<SX load='3j80' size='340' side='right' viewer='molstar' caption='[[3j80]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
<SX load='3j80' size='340' side='right' viewer='molstar' caption='[[3j80]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3j80]] is a 37 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_56498 Atcc 56498] and [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J80 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3j80]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J80 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j81|3j81]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j80 OCA], [https://pdbe.org/3j80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j80 RCSB], [https://www.ebi.ac.uk/pdbsum/3j80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j80 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j80 OCA], [https://pdbe.org/3j80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j80 RCSB], [https://www.ebi.ac.uk/pdbsum/3j80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j80 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RS27A_KLULA RS27A_KLULA]] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).  Ribosomal protein S27a is a component of the 40S subunit of the ribosome. [[https://www.uniprot.org/uniprot/RSSA_KLULA RSSA_KLULA]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. [[https://www.uniprot.org/uniprot/RS21_KLULA RS21_KLULA]] Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (By similarity). [[https://www.uniprot.org/uniprot/IF1A_YEAST IF1A_YEAST]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[https://www.uniprot.org/uniprot/SUI1_YEAST SUI1_YEAST]] Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.  
[https://www.uniprot.org/uniprot/RS21_KLULA RS21_KLULA] Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Atcc 56498]]
[[Category: Kluyveromyces lactis]]
[[Category: Kluyveromyces lactis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fernandez, I S]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Hussain, T]]
[[Category: Fernandez IS]]
[[Category: Llacer, J L]]
[[Category: Hussain T]]
[[Category: Ramakrishnan, V]]
[[Category: Llacer JL]]
[[Category: Savva, C G]]
[[Category: Ramakrishnan V]]
[[Category: Eukaryotic translation initiation]]
[[Category: Savva CG]]
[[Category: Ribosome]]
[[Category: Small ribosome subunit]]

Revision as of 14:17, 24 January 2024

CryoEM structure of 40S-eIF1-eIF1A preinitiation complex

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