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<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
<StructureSection load='6zmm' size='340' side='right'caption='[[6zmm]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6zmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6zmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NDRG1, CAP43, DRG1, RTP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [https://pdbe.org/6zmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [https://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmm OCA], [https://pdbe.org/6zmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmm RCSB], [https://www.ebi.ac.uk/pdbsum/6zmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN]] Charcot-Marie-Tooth disease type 4D. The disease is caused by variants affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN] Charcot-Marie-Tooth disease type 4D. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN]] Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.<ref>PMID:15247272</ref> <ref>PMID:15377670</ref> <ref>PMID:17786215</ref> <ref>PMID:9766676</ref>
[https://www.uniprot.org/uniprot/NDRG1_HUMAN NDRG1_HUMAN] Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.<ref>PMID:15247272</ref> <ref>PMID:15377670</ref> <ref>PMID:17786215</ref> <ref>PMID:9766676</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kursula, P]]
[[Category: Kursula P]]
[[Category: Mustonen, V]]
[[Category: Mustonen V]]
[[Category: Ruskamo, S]]
[[Category: Ruskamo S]]
[[Category: Lipid binding protein]]
[[Category: Metal binding protein]]
[[Category: Tumor suppressor]]
Retrieved from "https://proteopedia.org/6zmm"