7b6i: Difference between revisions

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<StructureSection load='7b6i' size='340' side='right'caption='[[7b6i]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='7b6i' size='340' side='right'caption='[[7b6i]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7b6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B6I FirstGlance]. <br>
<table><tr><td colspan='2'>[[7b6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B6I FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZE:4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one'>SZE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.069&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZE:4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one'>SZE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6i OCA], [http://pdbe.org/7b6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b6i RCSB], [http://www.ebi.ac.uk/pdbsum/7b6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6i OCA], [https://pdbe.org/7b6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b6i RCSB], [https://www.ebi.ac.uk/pdbsum/7b6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>
[https://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>  
 
==See Also==
*[[Mur ligase|Mur ligase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Douangamath A]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Douangamath, A]]
[[Category: Fairhead M]]
[[Category: Edwards, A M]]
[[Category: Koekemoer L]]
[[Category: Fairhead, M]]
[[Category: Krojer T]]
[[Category: Koekemoer, L]]
[[Category: Steindel M]]
[[Category: Krojer, T]]
[[Category: Talon R]]
[[Category: Structural genomic]]
[[Category: Von Delft F]]
[[Category: Steindel, M]]
[[Category: Talon, R]]
[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase drug target]]
[[Category: Biosynthetic protein]]
[[Category: Fragment screening]]
[[Category: Sgc]]
[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]]

Latest revision as of 12:22, 1 February 2024

Crystal structure of MurE from E.coli in complex with Z1373445602

7b6i, resolution 2.07Å

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