7ojo: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7ojo is ~~ON HOLD until Paper Publication~~

==Tankyrase 2 in complex with two small molecule fragments==

== Structural highlights ==

<table><tr><td colspan='2'>[[7ojo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJO OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7OJO FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VGZ:4-acetamido-~{N}-(2-methoxyphenyl)benzamide'>VGZ</scene>, <scene name='pdbligand=WQG:quinazolin-4(3H)-one'>WQG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7ojo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ojo OCA], [https://pdbe.org/7ojo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ojo RCSB], [https://www.ebi.ac.uk/pdbsum/7ojo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ojo ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>

~~Authors: Sowa, S.T., Lehtio, L.~~

==See Also==

*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]

~~Description~~: ~~Tankyrase 2 in complex with two small molecule fragments~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Sowa, S.T~~]]

__TOC__

[[Category: ~~Lehtio, L~~]]

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Lehtio L]]

[[Category: Sowa ST]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ojo is ON HOLD  until Paper Publication
+==Tankyrase 2 in complex with two small molecule fragments==
+<StructureSection load='7ojo' size='340' side='right'caption='[[7ojo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ojo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OJO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VGZ:4-acetamido-~{N}-(2-methoxyphenyl)benzamide'>VGZ</scene>, <scene name='pdbligand=WQG:quinazolin-4(3H)-one'>WQG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ojo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ojo OCA], [https://pdbe.org/7ojo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ojo RCSB], [https://www.ebi.ac.uk/pdbsum/7ojo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ojo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
-Authors: Sowa, S.T., Lehtio, L.
+==See Also==
+*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
-Description: Tankyrase 2 in complex with two small molecule fragments
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Sowa, S.T]]
+__TOC__
-[[Category: Lehtio, L]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Lehtio L]]
+[[Category: Sowa ST]]