7ozm: Difference between revisions

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<StructureSection load='7ozm' size='340' side='right'caption='[[7ozm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='7ozm' size='340' side='right'caption='[[7ozm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7ozm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZM FirstGlance]. <br>
<table><tr><td colspan='2'>[[7ozm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acylglycerol_lipase Acylglycerol lipase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.23 3.1.1.23] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ozm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ozm OCA], [https://pdbe.org/7ozm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ozm RCSB], [https://www.ebi.ac.uk/pdbsum/7ozm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ozm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ozm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ozm OCA], [https://pdbe.org/7ozm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ozm RCSB], [https://www.ebi.ac.uk/pdbsum/7ozm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ozm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MGLL_MYCTU MGLL_MYCTU]] Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl-rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl-rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1-monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1) (PubMed:17784850). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not whith a longest chain fatty acids (PubMed:17784850). Can also hydrolyze vinyl laurate (VC12), vinyl butyrate (VC4) and vinyl propionate (VC3) (PubMed:17784850).<ref>PMID:17784850</ref> <ref>PMID:22405030</ref>
[https://www.uniprot.org/uniprot/MGLL_MYCTU MGLL_MYCTU] Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl-rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl-rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1-monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1) (PubMed:17784850). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not whith a longest chain fatty acids (PubMed:17784850). Can also hydrolyze vinyl laurate (VC12), vinyl butyrate (VC4) and vinyl propionate (VC3) (PubMed:17784850).<ref>PMID:17784850</ref> <ref>PMID:22405030</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7ozm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7ozm" style="background-color:#fffaf0;"></div>
==See Also==
*[[Lipase 3D Structures|Lipase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acylglycerol lipase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aschauer, P]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Grininger, C]]
[[Category: Aschauer P]]
[[Category: Oberer, M]]
[[Category: Grininger C]]
[[Category: Pavkov-Keller, T]]
[[Category: Oberer M]]
[[Category: Hydrolase]]
[[Category: Pavkov-Keller T]]
[[Category: Monoacylglycerol lipase]]
[[Category: Mycobacterium tuberculosis]]
Retrieved from "https://proteopedia.org/7ozm"