7yxw: Difference between revisions
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==== | ==Structure of the p22phox A200G mutant in complex with p47phox peptide== | ||
<StructureSection load='7yxw' size='340' side='right'caption='[[7yxw]]' scene=''> | <StructureSection load='7yxw' size='340' side='right'caption='[[7yxw]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7yxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXW FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxw OCA], [https://pdbe.org/7yxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxw RCSB], [https://www.ebi.ac.uk/pdbsum/7yxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxw ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxw OCA], [https://pdbe.org/7yxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxw RCSB], [https://www.ebi.ac.uk/pdbsum/7yxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN] Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD) [MIM:[https://omim.org/entry/233690 233690]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2243141</ref> <ref>PMID:1415254</ref> <ref>PMID:1763037</ref> <ref>PMID:8168815</ref> <ref>PMID:7964505</ref> <ref>PMID:10910929</ref> <ref>PMID:10759707</ref> <ref>PMID:10914676</ref> <ref>PMID:18422995</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.<ref>PMID:15824103</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Z | [[Category: Cukier CD]] | ||
[[Category: Komjati B]] | |||
[[Category: Szlavik Z]] | |||
[[Category: Vuillard LM]] | |||
