2yly: Difference between revisions

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<StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yy4|1yy4]], [[1u3s|1u3s]], [[1x78|1x78]], [[1qkm|1qkm]], [[1u3r|1u3r]], [[1l2j|1l2j]], [[2fsz|2fsz]], [[1x7j|1x7j]], [[1x7b|1x7b]], [[1u9e|1u9e]], [[1x76|1x76]], [[1nde|1nde]], [[1yye|1yye]], [[2jj3|2jj3]], [[1u3q|1u3q]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [https://pdbe.org/2yly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [https://www.ebi.ac.uk/pdbsum/2yly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yly ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [https://pdbe.org/2yly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [https://www.ebi.ac.uk/pdbsum/2yly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yly ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.  
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Armour, D]]
[[Category: Armour D]]
[[Category: Barker, C]]
[[Category: Barker C]]
[[Category: Bazin, R]]
[[Category: Bazin R]]
[[Category: Bess, K]]
[[Category: Bess K]]
[[Category: Brown, A]]
[[Category: Brown A]]
[[Category: Ellis, D]]
[[Category: Ellis D]]
[[Category: Favor, D]]
[[Category: Favor D]]
[[Category: MacKenny, M]]
[[Category: MacKenny M]]
[[Category: Phillips, C]]
[[Category: Phillips C]]
[[Category: Pullen, N]]
[[Category: Pullen N]]
[[Category: Roberts, L R]]
[[Category: Roberts LR]]
[[Category: Stennett, A]]
[[Category: Stennett A]]
[[Category: Strand, L]]
[[Category: Strand L]]
[[Category: Styles, M]]
[[Category: Styles M]]
[[Category: Receptor]]
Retrieved from "https://proteopedia.org/2yly"