1a92: Difference between revisions

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<StructureSection load='1a92' size='340' side='right'caption='[[1a92]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1a92' size='340' side='right'caption='[[1a92]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1a92]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hdv Hdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A92 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1a92]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A92 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a92 OCA], [https://pdbe.org/1a92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a92 RCSB], [https://www.ebi.ac.uk/pdbsum/1a92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a92 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a92 OCA], [https://pdbe.org/1a92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a92 RCSB], [https://www.ebi.ac.uk/pdbsum/1a92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a92 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SHDAG_HDVAM SHDAG_HDVAM]] Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).  
[https://www.uniprot.org/uniprot/SHDAG_HDVAM SHDAG_HDVAM] Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a92 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a92 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
BACKGROUND: The hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV). Coinfection with HBV and HDV causes severe liver disease in humans. The small 195 amino-acid form of the hepatitis delta antigen (HDAg) functions as a trans activator of HDV replication. A larger form of the protein containing a 19 amino acid C-terminal extension inhibits viral replication. Both of these functions are mediated in part by a stretch of amino acids predicted to form a coiled coil (residues 13-48) that is common to both forms. It is believed that HDAg forms dimers and higher ordered structures through this coiled-coil region. RESULTS: The high-resolution crystal structure of a synthetic peptide corresponding to residues 12 to 60 of HDAg has been solved. The peptide forms an antiparallel coiled coil, with hydrophobic residues near the termini of each peptide forming an extensive hydrophobic core with residues C-terminal to the coiled-coil domain in the dimer protein. The structure shows how HDAg forms dimers, but also shows the dimers forming an octamer that forms a 50 A ring lined with basic sidechains. This is confirmed by cross-linking studies of full-length recombinant small HDAg. CONCLUSIONS: HDAg dimerizes through an antiparallel coiled coil. Dimers then associate further to form octamers through residues in the coiled-coil domain and residues C-terminal to this region. Our findings suggest that the structure of HDAg represents a previously unseen organization of a nucleocapsid protein and raise the possibility that the N terminus may play a role in binding the viral RNA.
Structural basis of the oligomerization of hepatitis delta antigen.,Zuccola HJ, Rozzelle JE, Lemon SM, Erickson BW, Hogle JM Structure. 1998 Jul 15;6(7):821-30. PMID:9687364<ref>PMID:9687364</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1a92" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hdv]]
[[Category: Hepatitis delta virus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hogle, J M]]
[[Category: Hogle JM]]
[[Category: Zuccola, H J]]
[[Category: Zuccola HJ]]
[[Category: Coiled-coil]]
[[Category: Hepatitis delta]]
[[Category: Leucine zipper]]
[[Category: Oligomerization]]

Latest revision as of 06:28, 7 February 2024

OLIGOMERIZATION DOMAIN OF HEPATITIS DELTA ANTIGEN

1a92, resolution 1.80Å

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