1c3h: Difference between revisions
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<StructureSection load='1c3h' size='340' side='right'caption='[[1c3h]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1c3h' size='340' side='right'caption='[[1c3h]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1c3h]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1c3h]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C3H FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c3h OCA], [https://pdbe.org/1c3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c3h RCSB], [https://www.ebi.ac.uk/pdbsum/1c3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c3h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c3h OCA], [https://pdbe.org/1c3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c3h RCSB], [https://www.ebi.ac.uk/pdbsum/1c3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c3h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ADIPO_MOUSE ADIPO_MOUSE] Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.<ref>PMID:11479627</ref> <ref>PMID:11479628</ref> <ref>PMID:12840063</ref> <ref>PMID:15760892</ref> <ref>PMID:15734737</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Boggon | [[Category: Boggon T]] | ||
[[Category: Scherer | [[Category: Scherer P]] | ||
[[Category: Shapiro | [[Category: Shapiro L]] | ||
