1q0p: Difference between revisions
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'''A domain of Factor B''' | '''A domain of Factor B''' | ||
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[[Category: Bhattacharya, A A.]] | [[Category: Bhattacharya, A A.]] | ||
[[Category: Liddington, R C.]] | [[Category: Liddington, R C.]] | ||
[[Category: | [[Category: A domain]] | ||
[[Category: | [[Category: Factor b]] | ||
[[Category: | [[Category: I domain]] | ||
[[Category: | [[Category: Mac-1]] | ||
[[Category: | [[Category: Von willebrand factor]] | ||
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Revision as of 02:43, 3 May 2008
A domain of Factor B
Overview
Complement factor B is a 90 kDa protein consisting of three domains: a three-module complement control protein, a von Willebrand factor A domain, and a C-terminal serine protease (SP) domain that adopts a default inactive (zymogen) conformation. The interaction between factor B and pathogen-bound C3b is mediated by its A domain, triggering a conformational change in factor B that ultimately creates the "C3 convertase" of the alternative complement pathway. We report the crystal structure of the A domain from factor B and show that it contains an integrin-like MIDAS motif that adopts the "open" conformation typical of integrin-ligand complexes, with an acidic residue (provided by a fortuitous crystal contact) completing the coordination of the metal ion. Modeling studies indicate that the factor B A domain can also adopt the closed conformation, supporting the hypothesis that an "integrin-like switch" is conserved in complement proteins and perhaps in 60 other A domains found within the human proteome.
Disease
Known disease associated with this structure: Macular degeneration, age-related, reduced risk of OMIM:[138470]
About this Structure
1Q0P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation., Bhattacharya AA, Lupher ML Jr, Staunton DE, Liddington RC, Structure. 2004 Mar;12(3):371-8. PMID:15016353 Page seeded by OCA on Sat May 3 05:43:21 2008
