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<StructureSection load='1jgs' size='340' side='right'caption='[[1jgs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1jgs' size='340' side='right'caption='[[1jgs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGS FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgs OCA], [https://pdbe.org/1jgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgs RCSB], [https://www.ebi.ac.uk/pdbsum/1jgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgs OCA], [https://pdbe.org/1jgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgs RCSB], [https://www.ebi.ac.uk/pdbsum/1jgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MARR_ECOLI MARR_ECOLI]] Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.  
[https://www.uniprot.org/uniprot/MARR_ECOLI MARR_ECOLI] Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgs ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution.,Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:11473263<ref>PMID:11473263</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1jgs" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Alekshun, M N]]
[[Category: Alekshun MN]]
[[Category: Head, J F]]
[[Category: Head JF]]
[[Category: Levy, S B]]
[[Category: Levy SB]]
[[Category: Mealy, T R]]
[[Category: Mealy TR]]
[[Category: Seaton, B A]]
[[Category: Seaton BA]]
[[Category: Antibiotic resistance]]
[[Category: Dna-binding]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]

Latest revision as of 07:39, 7 February 2024

Multiple Antibiotic Resistance Repressor, MarR

1jgs, resolution 2.30Å

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