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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6zwt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_SDF Acinetobacter baumannii SDF]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZWT FirstGlance]. <br>
<table><tr><td colspan='2'>[[6zwt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_SDF Acinetobacter baumannii SDF]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZWT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zwt OCA], [https://pdbe.org/6zwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zwt RCSB], [https://www.ebi.ac.uk/pdbsum/6zwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zwt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zwt OCA], [https://pdbe.org/6zwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zwt RCSB], [https://www.ebi.ac.uk/pdbsum/6zwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zwt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/B0VPC9_ACIBS B0VPC9_ACIBS]  
[https://www.uniprot.org/uniprot/B0VPC9_ACIBS B0VPC9_ACIBS]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcriptional regulator plays a pivotal role in the pathogenesis of diverse A. baumannii clinical strains in multiple murine and G. mellonella invertebrate infection models. We identified OmpR-regulated genes using RNA sequencing and further validated two genes whose expression can be used as robust biomarker to quantify OmpR inhibition in A. baumannii. Moreover, the determination of the structure of the OmpR DNA binding domain of A. baumannii and the development of in vitro protein-DNA binding assays enabled the identification of an OmpR small molecule inhibitor. We conclude that OmpR is a valid and unexplored target to fight A. baumannii infections and we believe that the described platform combining in silico methods, in vitro OmpR inhibitory assays and in vivo G. mellonella surrogate infection model will facilitate future drug discovery programs.
Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis.,Trebosc V, Lucchini V, Narwal M, Wicki B, Gartenmann S, Schellhorn B, Schill J, Bourotte M, Frey D, Grunberg J, Trauner A, Ferrari L, Felici A, Champion OL, Gitzinger M, Lociuro S, Kammerer RA, Kemmer C, Pieren M Virulence. 2022 Dec;13(1):1868-1883. doi: 10.1080/21505594.2022.2135273. PMID:36261919<ref>PMID:36261919</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6zwt" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Response regulator 3D structure|Response regulator 3D structure]]
*[[Response regulator 3D structure|Response regulator 3D structure]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 07:51, 7 February 2024

Crystal structure of DNA-binding domain of OmpR of two-component system of Acinetobacter baumannii

6zwt, resolution 2.20Å

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