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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3jax]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAX FirstGlance]. <br>
<table><tr><td colspan='2'>[[3jax]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JAX FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dtp|3dtp]], [[1i84|1i84]], [[2fxm|2fxm]], [[1b7t|1b7t]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 23&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jax OCA], [https://pdbe.org/3jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jax RCSB], [https://www.ebi.ac.uk/pdbsum/3jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jax ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jax OCA], [https://pdbe.org/3jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jax RCSB], [https://www.ebi.ac.uk/pdbsum/3jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jax ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A0R4I956_SCHMA A0A0R4I956_SCHMA]
Muscle tissues are classically divided into two major types, depending on the presence or absence of striations. In striated muscles, the actin filaments are anchored at Z-lines and the myosin and actin filaments are in register, whereas in smooth muscles, the actin filaments are attached to dense bodies and the myosin and actin filaments are out of register. The structure of the filaments in smooth muscles is also different from that in striated muscles. Here we have studied the structure of myosin filaments from the smooth muscles of the human parasite Schistosoma mansoni. We find, surprisingly, that they are indistinguishable from those in an arthropod striated muscle. This structural similarity is supported by sequence comparison between the schistosome myosin II heavy chain and known striated muscle myosins. In contrast, the actin filaments of schistosomes are similar to those of smooth muscles, lacking troponin-dependent regulation. We conclude that schistosome muscles are hybrids, containing striated muscle-like myosin filaments and smooth muscle-like actin filaments in a smooth muscle architecture. This surprising finding has broad significance for understanding how muscles are built and how they evolved, and challenges the paradigm that smooth and striated muscles always have distinctly different components.
 
An invertebrate smooth muscle with striated muscle myosin filaments.,Sulbaran G, Alamo L, Pinto A, Marquez G, Mendez F, Padron R, Craig R Proc Natl Acad Sci U S A. 2015 Oct 6. pii: 201513439. PMID:26443857<ref>PMID:26443857</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3jax" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Schistosoma mansoni]]
[[Category: Schistosoma mansoni]]
[[Category: Alamo, L]]
[[Category: Alamo L]]
[[Category: Craig, R]]
[[Category: Craig R]]
[[Category: Marquez, G]]
[[Category: Marquez G]]
[[Category: Mendez, F]]
[[Category: Mendez F]]
[[Category: Padron, R]]
[[Category: Padron R]]
[[Category: Pinto, A]]
[[Category: Pinto A]]
[[Category: Sulbaran, G]]
[[Category: Sulbaran G]]
[[Category: Coiled-coil]]
[[Category: Contractile protein]]
[[Category: Essential light chain]]
[[Category: Heavy meromyosin]]
[[Category: Motor protein]]
[[Category: Muscle protein]]
[[Category: Myosin subfragment 2]]
[[Category: Regulatory light chain]]
[[Category: Smooth muscle]]

Revision as of 08:42, 7 February 2024

Heavy meromyosin from Schistosoma mansoni muscle thick filament by negative stain EM

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