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<SX load='3jcs' size='340' side='right' viewer='molstar' caption='[[3jcs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<SX load='3jcs' size='340' side='right' viewer='molstar' caption='[[3jcs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3jcs]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JCS FirstGlance]. <br>
<table><tr><td colspan='2'>[[3jcs]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JCS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jcs OCA], [https://pdbe.org/3jcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jcs RCSB], [https://www.ebi.ac.uk/pdbsum/3jcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jcs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jcs OCA], [https://pdbe.org/3jcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jcs RCSB], [https://www.ebi.ac.uk/pdbsum/3jcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jcs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/E9BQD7_LEIDB E9BQD7_LEIDB]] Binds to the 23S rRNA.[RuleBase:RU000576]
[https://www.uniprot.org/uniprot/E9BKR3_LEIDB E9BKR3_LEIDB]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Leishmania is a single-cell eukaryotic parasite of the Trypanosomatidae family, whose members cause an array of tropical diseases. The often fatal outcome of infections, lack of effective vaccines, limited selection of therapeutic drugs, and emerging resistant strains, underline the need to develop strategies to combat these pathogens. The Trypanosomatid ribosome has recently been highlighted as a promising therapeutic target due to structural features that are distinct from other eukaryotes. Here, we present the 2.8-A resolution structure of the Leishmania donovani large ribosomal subunit (LSU) derived from a cryo-EM map, further enabling the structural observation of eukaryotic rRNA modifications that play a significant role in ribosome assembly and function. The structure illustrates the unique fragmented nature of leishmanial LSU rRNA and highlights the irregular distribution of rRNA modifications in Leishmania, a characteristic with implications for anti-parasitic drug development.
 
2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.,Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G Cell Rep. 2016 Jul 12;16(2):288-94. doi: 10.1016/j.celrep.2016.06.014. Epub 2016 , Jun 30. PMID:27373148<ref>PMID:27373148</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3jcs" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Leishmania donovani]]
[[Category: Leishmania donovani]]
[[Category: Bashan, A]]
[[Category: Bashan A]]
[[Category: Halfon, Y]]
[[Category: Halfon Y]]
[[Category: Jaffe, C L]]
[[Category: Jaffe CL]]
[[Category: Matzov, D]]
[[Category: Matzov D]]
[[Category: Rozenberg, H]]
[[Category: Rozenberg H]]
[[Category: Shalev-Benami, M]]
[[Category: Shalev-Benami M]]
[[Category: Skiniotis, G]]
[[Category: Skiniotis G]]
[[Category: Yonath, A]]
[[Category: Yonath A]]
[[Category: Zackay, A]]
[[Category: Zackay A]]
[[Category: Zhang, Y]]
[[Category: Zhang Y]]
[[Category: Zimmerman, E]]
[[Category: Zimmerman E]]
[[Category: Eukaryotic parasite]]
[[Category: Ribosome]]
[[Category: The large ribosomal subunit]]

Revision as of 08:44, 7 February 2024

2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania

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