3k2a: Difference between revisions
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<StructureSection load='3k2a' size='340' side='right'caption='[[3k2a]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='3k2a' size='340' side='right'caption='[[3k2a]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3k2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3k2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K2A FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
< | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2a OCA], [https://pdbe.org/3k2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2a RCSB], [https://www.ebi.ac.uk/pdbsum/3k2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2a OCA], [https://pdbe.org/3k2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2a RCSB], [https://www.ebi.ac.uk/pdbsum/3k2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MEIS2_HUMAN MEIS2_HUMAN] Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.<ref>PMID:10764806</ref> <ref>PMID:11279116</ref> <ref>PMID:21746878</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Battaile | [[Category: Battaile KP]] | ||
[[Category: Beletskaya | [[Category: Beletskaya I]] | ||
[[Category: Chirgadze | [[Category: Chirgadze NY]] | ||
[[Category: Gordon | [[Category: Gordon E]] | ||
[[Category: Lam | [[Category: Lam K]] | ||
[[Category: Lam | [[Category: Lam R]] | ||
[[Category: Pai | [[Category: Pai EF]] | ||
[[Category: Romanov | [[Category: Romanov V]] | ||
[[Category: Soloveychik | [[Category: Soloveychik M]] | ||
Latest revision as of 08:44, 7 February 2024
Crystal structure of the homeobox domain of human homeobox protein Meis2
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