5qdb: Difference between revisions

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==Crystal structure of BACE complex with BMC002==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDB OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5QDB FirstGlance].

<table><tr><td colspan='2'>[[5qdb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDB OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5QDB FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5qdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdb OCA], [https://pdbe.org/5qdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdb RCSB], [https://www.ebi.ac.uk/pdbsum/5qdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdb ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAV:(3S,14R,16S)-16-[(1R)-1-HYDROXY-2-{[3-(1-METHYLETHYL)BENZYL]AMINO}ETHYL]-3,4,14-TRIMETHYL-1,4-DIAZACYCLOHEXADECANE-2,5-DIONE'>BAV</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5qdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdb OCA], [https://pdbe.org/5qdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdb RCSB], [https://www.ebi.ac.uk/pdbsum/5qdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdb ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Rondeau, JM, Shao, C, Yang, H~~, Burley, SK~~]]

[[Category: Burley SK]]

[[Category: Rondeau JM]]

[[Category: Shao C]]

[[Category: Yang H]]

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@@ Line 1: / Line 1: @@
 ==Crystal structure of BACE complex with BMC002==
-<StructureSection load='5qdb' size='340' side='right'caption='[[5qdb]]' scene=''>
+<StructureSection load='5qdb' size='340' side='right'caption='[[5qdb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5qdb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDB FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdb OCA], [https://pdbe.org/5qdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdb RCSB], [https://www.ebi.ac.uk/pdbsum/5qdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdb ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAV:(3S,14R,16S)-16-[(1R)-1-HYDROXY-2-{[3-(1-METHYLETHYL)BENZYL]AMINO}ETHYL]-3,4,14-TRIMETHYL-1,4-DIAZACYCLOHEXADECANE-2,5-DIONE'>BAV</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdb OCA], [https://pdbe.org/5qdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdb RCSB], [https://www.ebi.ac.uk/pdbsum/5qdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdb ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Rondeau, JM, Shao, C, Yang, H, Burley, SK]]
+[[Category: Burley SK]]
+[[Category: Rondeau JM]]
+[[Category: Shao C]]
+[[Category: Yang H]]