8i9m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 8i9m is ~~ON HOLD until Paper Publication~~

==The RAGE and HMGB1 complex==

~~Authors~~: ~~Han~~, C.W., ~~Kim~~, H.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[8i9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I9M FirstGlance]. <br>

~~Description~~: ~~The RAGE~~ and ~~HMGB1~~ complex

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.19Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i9m OCA], [https://pdbe.org/8i9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i9m RCSB], [https://www.ebi.ac.uk/pdbsum/8i9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i9m ProSAT]</span></td></tr>

[[Category: Han~~, C.W~~]]

</table>

[[Category: Kim~~, H.J~~]]

== Function ==

[https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Han CW]]

[[Category: Kim HJ]]

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-'''Unreleased structure'''
-The entry 8i9m is ON HOLD  until Paper Publication
+==The RAGE and HMGB1 complex==
+<StructureSection load='8i9m' size='340' side='right'caption='[[8i9m]], [[Resolution|resolution]] 5.19&Aring;' scene=''>
-Authors: Han, C.W., Kim, H.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8i9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I9M FirstGlance]. <br>
-Description: The RAGE and HMGB1 complex
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.19&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i9m OCA], [https://pdbe.org/8i9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i9m RCSB], [https://www.ebi.ac.uk/pdbsum/8i9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i9m ProSAT]</span></td></tr>
-[[Category: Han, C.W]]
+</table>
-[[Category: Kim, H.J]]
+== Function ==
+[https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Han CW]]
+[[Category: Kim HJ]]