8v1l: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8v1l is ~~ON HOLD~~

==Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule==

~~Authors~~: ~~Hughes~~, M.P., ~~Taylor~~, J.P.

== Structural highlights ==

<table><tr><td colspan='2'>[[8v1l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V1L OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8V1L FirstGlance].

~~Description~~: ~~Crystal structure~~ of the ~~NTF2L domain of human G3BP1~~ in ~~complex with small molecule~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y9M:N-[(2S)-2-fluoro-4,4-dimethylpentanoyl]-3-hydroxy-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-D-alanyl-N-benzyl-N,O-dimethyl-L-homoserinamide'>Y9M</scene></td></tr>

[[Category: Hughes~~, M.P~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8v1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v1l OCA], [https://pdbe.org/8v1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v1l RCSB], [https://www.ebi.ac.uk/pdbsum/8v1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v1l ProSAT]</td></tr>

[[Category: Taylor~~, J.P~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Hughes MP]]

[[Category: Taylor JP]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8v1l is ON HOLD
+==Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule==
+<StructureSection load='8v1l' size='340' side='right'caption='[[8v1l]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
-Authors: Hughes, M.P., Taylor, J.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8v1l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V1L FirstGlance]. <br>
-Description: Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y9M:N-[(2S)-2-fluoro-4,4-dimethylpentanoyl]-3-hydroxy-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-D-alanyl-N-benzyl-N,O-dimethyl-L-homoserinamide'>Y9M</scene></td></tr>
-[[Category: Hughes, M.P]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v1l OCA], [https://pdbe.org/8v1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v1l RCSB], [https://www.ebi.ac.uk/pdbsum/8v1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v1l ProSAT]</span></td></tr>
-[[Category: Taylor, J.P]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hughes MP]]
+[[Category: Taylor JP]]