1q6k: Difference between revisions
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'''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate''' | '''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate''' | ||
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[[Category: Willard, D H.]] | [[Category: Willard, D H.]] | ||
[[Category: Wright, L L.]] | [[Category: Wright, L L.]] | ||
[[Category: | [[Category: Cathepsin k]] | ||
[[Category: | [[Category: Catk]] | ||
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Revision as of 02:55, 3 May 2008
Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate
Overview
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.
About this Structure
1Q6K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors., Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342 Page seeded by OCA on Sat May 3 05:55:35 2008
