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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qza OCA], [https://pdbe.org/1qza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qza RCSB], [https://www.ebi.ac.uk/pdbsum/1qza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qza ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qza OCA], [https://pdbe.org/1qza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qza RCSB], [https://www.ebi.ac.uk/pdbsum/1qza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qza ProSAT]</span></td></tr>
</table>
</table>
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== Publication Abstract from PubMed ==
Aminoacyl-tRNAs (aa-tRNAs) are delivered to the ribosome as part of the ternary complex of aa-tRNA, elongation factor Tu (EF-Tu) and GTP. Here, we present a cryo-electron microscopy (cryo-EM) study, at a resolution of approximately 9 A, showing that during the incorporation of the aa-tRNA into the 70S ribosome of Escherichia coli, the flexibility of aa-tRNA allows the initial codon recognition and its accommodation into the ribosomal A site. In addition, a conformational change observed in the GTPase-associated center (GAC) of the ribosomal 50S subunit may provide the mechanism by which the ribosome promotes a relative movement of the aa-tRNA with respect to EF-Tu. This relative rearrangement seems to facilitate codon recognition by the incoming aa-tRNA, and to provide the codon-anticodon recognition-dependent signal for the GTPase activity of EF-Tu. From these new findings we propose a mechanism that can explain the sequence of events during the decoding of mRNA on the ribosome.
Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy.,Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:14566331<ref>PMID:14566331</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1qza" style="background-color:#fffaf0;"></div>
== References ==
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Latest revision as of 08:19, 14 February 2024

Coordinates of the A/T site tRNA model fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome

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