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<StructureSection load='1xpx' size='340' side='right'caption='[[1xpx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1xpx' size='340' side='right'caption='[[1xpx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xpx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XPX FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xpx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPX FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pros ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpx OCA], [http://pdbe.org/1xpx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xpx RCSB], [http://www.ebi.ac.uk/pdbsum/1xpx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpx OCA], [https://pdbe.org/1xpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpx RCSB], [https://www.ebi.ac.uk/pdbsum/1xpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PROS_DROME PROS_DROME]] Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding. Not required for the specification of neuronal identity. May regulate transcription by binding to DNA.<ref>PMID:1720353</ref> <ref>PMID:1842358</ref> <ref>PMID:1540176</ref> <ref>PMID:11051550</ref>
[https://www.uniprot.org/uniprot/PROS_DROME PROS_DROME] Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding. Not required for the specification of neuronal identity. May regulate transcription by binding to DNA.<ref>PMID:1720353</ref> <ref>PMID:1842358</ref> <ref>PMID:1540176</ref> <ref>PMID:11051550</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpx ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a complex between the novel homeodomain of the neural transcription factor Prospero and DNA shows that the invariant residues Lys1290, Asn1294, and Asp1297 make specific contacts with the noncanonical DNA binding site. The overall structure includes the homeodomain and the adjacent Prospero domain and confirms that they act as a single structural unit, a Homeo-Prospero domain. The Prospero domain facilitates the proper alignment of the protein on the DNA. Knowledge of the structure reconciles two different DNA sequences that have been proposed as transcriptional targets for Prospero. As in the apo structure, the C terminus of the Prospero domain shields a short helix within the homeodomain that includes a nuclear export signal (NES). The structural results suggest that exposure of the NES is not coupled directly to DNA binding. We propose a DNA recognition mechanism specific to Prospero-type homeodomains in developing cells.
Structural basis of Prospero-DNA interaction: implications for transcription regulation in developing cells.,Yousef MS, Matthews BW Structure. 2005 Apr;13(4):601-7. PMID:15837198<ref>PMID:15837198</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1xpx" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Matthews, B W]]
[[Category: Matthews BW]]
[[Category: Yousef, M S]]
[[Category: Yousef MS]]
[[Category: Homeodomain]]
[[Category: Neural cell development]]
[[Category: Prospero]]
[[Category: Protein-dna binding]]
[[Category: Transcription regulation-dna complex]]

Latest revision as of 08:52, 14 February 2024

Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells

1xpx, resolution 2.80Å

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