1zvn: Difference between revisions

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<StructureSection load='1zvn' size='340' side='right'caption='[[1zvn]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
<StructureSection load='1zvn' size='340' side='right'caption='[[1zvn]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1zvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVN FirstGlance]. <br>
<table><tr><td colspan='2'>[[1zvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVN FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MNcadherin ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvn OCA], [https://pdbe.org/1zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvn RCSB], [https://www.ebi.ac.uk/pdbsum/1zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvn OCA], [https://pdbe.org/1zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvn RCSB], [https://www.ebi.ac.uk/pdbsum/1zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CAD20_CHICK CAD20_CHICK]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.<ref>PMID:12007407</ref> <ref>PMID:15992777</ref> <ref>PMID:16564015</ref>
[https://www.uniprot.org/uniprot/CAD20_CHICK CAD20_CHICK] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.<ref>PMID:12007407</ref> <ref>PMID:15992777</ref> <ref>PMID:16564015</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zvn ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zvn ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.
Type II cadherin ectodomain structures: implications for classical cadherin specificity.,Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015<ref>PMID:16564015</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1zvn" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bahna, F]]
[[Category: Bahna F]]
[[Category: Chen, C P]]
[[Category: Chen CP]]
[[Category: Ciatto, C]]
[[Category: Ciatto C]]
[[Category: Honig, B]]
[[Category: Honig B]]
[[Category: Jessell, T M]]
[[Category: Jessell TM]]
[[Category: Patel, S D]]
[[Category: Patel SD]]
[[Category: Price, S R]]
[[Category: Price SR]]
[[Category: Rajebhosale, M]]
[[Category: Rajebhosale M]]
[[Category: Schieren, I]]
[[Category: Schieren I]]
[[Category: Shapiro, L]]
[[Category: Shapiro L]]
[[Category: Cadherin]]
[[Category: Cell adhesion]]

Latest revision as of 09:07, 14 February 2024

Crystal structure of chick MN-cadherin EC1

1zvn, resolution 2.16Å

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